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Keywords: drug addiction; psychostimulants; opiates; alcohol; glutamate; behavioral pharmacology; optogenetics; preclinical models
We are interested in examining how abused drugs affect the brain on a neurobiological level. Specifically, what long-lasting changes do abused drugs produce in the brain that ultimately result in dependence and addiction? Can these changes be minimized or reversed? What makes some individuals vulnerable to addiction while others are resilient? Under what circumstances, and in what brain regions, do drugs produce toxic effects on neurons and other cell types? Given the poor outcomes of existing treatments for addictive disorders, our ultimate goal is to identify novel biological targets for innovative therapies that can be integrated into other treatment approaches to facilitate healing of the addicted brain.
Current research projects in the laboratory utilize model organisms to examine:
Dr. Olive received his undergraduate degree in Psychology from UC San Diego, and his doctoral degree in Neuroscience from UCLA. His postdoctoral research was performed at Stanford University and the University of California at San Francisco. His research has been published in journals such as Psychopharmacology, Biological Psychiatry, Journal of Neuroscience, and Nature Neuroscience, and he currently serves on the editorial boards for Neuropsychopharmacology, Addiction Biology, Neuropharmacology, and Frontiers in Pharmacology. Dr. Olive’s research is supported by the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse. He is a member of the ASU Leadership Academy Neuroscience team and was previously nominated for the Zebulon Pearce Distinguished Teaching Award.
Jonna M. Leyrer-Jackson, Ph.D.
Lauren E. Hood, Ph.D.
Seven E. Tomek, Doctoral Student, Behavioral Neuroscience, Department of Psychology
An alumni of ASU, Ms. Tomek earned her Master’s degree in Psychology from the University of North Carolina at Wilmington. She is currently enrolled in the Behavioral Neuroscience graduate program in the Department of Psychology, and is interested in studying deficits in social behaviors in opiate addiction and biological approaches to restoring social function during recovery.
Erin Nagy, Research Analyst Assistant
Former Postdoctoral Fellows:
Peter Kufahl, PhD; Software Engineer, Praxis Resources
Sara Taylor, PhDK Assistant Professor, Department of Psychology, Hendrix College
Former graduate students:
Amber LaCrosse, PhD; Postdoctoral Research Fellow, Aurora Research Institute
Candace Lewis, PhD; Postdoctoral Fellow, ASU Department of Psychology and Translational Genomics Research Institute
Lucas Watterson, PhD; Medical Science Liaison, Assurex Health
Allison Baker, Doctoral student in Neuroscience, University of Pennsylvania
Cory Casterline, Pharmacy student, Midwestern University
Lauren Hood, Doctoral student in Neuroscience, University of Washington
Meaghan Johnson, Copyright Coordinator, Sony Music Entertainment
Natali Nemirovsky, Staff Nurse, Inova Fairfax Hospital
Kelsey Staudinger, Doctoral student in Osteopathic Medicine, Campbell University
Scott Wegner, Staff Research Associate, UCSF Department of Neurology
Stephanie Yahn, Doctoral student in Neuroscience, University of Miami
Simmons SJ, Leyrer-Jackson J4, Oliver C, Hicks C, Muschamp JW, Rawls SM, Olive MF. DARK classics in chemical neuroscience: cathinone-derived psychostimulants. ACS Chemical Neuroscience 9:2379-2394, 2018.
Gipson CD, Olive MF. Structural plasticity of dendritic spines – root or result of behavior? Genes, Brain and Behavior 16:101-117, 2017.
Olive MF. Heroin. In series: Understanding Drugs (DJ Triggle, consulting ed), Chelsea House Publishers/InfoBase: New York, NY, 102 pp., 2017.
Taylor SB, Watterson LR, Kufahl PR, Nemirovsky NE, Tomek SE, Conrad CD, Olive MF. Chronic variable stress and intravenous methamphetamine self-administration – role of individual differences in behavioral and physiological reactivity to novelty. Neuropharmacology. 108:353-363, 2016.
Olive MF. Glutamate receptors and drug addiction. In: The Neuropathology of Drug Addictions and Substance Misuse – Volume 3 (Preedy VR, ed), Elsevier Publishers, New York, 2016, pp. 102-110.
Drug addiction is complex, and Arizona State University neuroscientist Foster Olive has spent his career working to unravel why and how the brain becomes addicted to drugs.
The ASU Department of Psychology recently promoted Olive from associate professor to full professor because of his research efforts
Although it has caused health effects in the past, LSD should not be lumped in with other recreational drugs. “LSD is believed to reduce our sensory filters that normally block out unnecessary sensory information, but also cause the brain to perceive sensations that are not actually present," Olive said. Read more in the State Press, LSD is in a league of its own (posted 11 Sep, 2016, photo courtesy of Chuck Dries).
At age 28, ASU alum Candace Lewis is both a Bisgrove Scholar and a Fulbright Scholar. Read more in Discovering what makes us tick ( ASU Now, 24 Nov, 2015).
After working in Dr. Olive's lab, SoLS student, Brian Burrows, decides to pursues neuroscience research and medical school. Read more about Brian's story and accomplishments including his award as “Student of the Year in Biological Sciences – Animal Physiology and Behavior” (ASU Now, 15 May, 2015)